This issue is fixed as of Crossover Games 8.1.3 when it fixed a bug in the Radeon cards that screwed up things like bloom and underwater distortion.
However if you do not have this version and u get that weird black screen with glowing icons trailing around the window in L4D there is a simple console command to solve the issue.
NOTE: this requires one to activate sv_cheats 1 in the game and therefore disables achievements and any hope of online play (also nulls the effect experienced when one is sprayed with Boomer Bile. )
To temporarily fix this issue one loads up Left 4 Dead like normal. When at the main menu go into the Options menu and then the Keyboard menu and check that "Developer Console" is "enabled".
If it is then start a single player game.
If not... enable it.
When in game press the "~" button on your keyboard to bring up the console.
Then type: sv_cheats 1
and press enter
this activates cheats which is required to disable the overlaying post process.
Then type: mat_postprocess_enable 0
and press enter
This disables any post processes such as overlays, bloom, etc.
press ESC on your keyboard to return to the game.
*AGAIN! THIS WAS FIXED IN VERSION 8.1.3 OF CO GAMES!*