I have Fedora 32, and Crossover 19.0.2-1 (the latest). It seems it doesn't work because it can't install the dbus-python package.

I attach the output from the console:

/opt/cxoffice/bin/crossover

_g_io_module_get_default: Found default implementation gvfs (GDaemonVfs) for ‘gio-vfs’

_g_io_module_get_default: Found default implementation dconf (DConfSettingsBackend) for ‘gsettings-backend’

watch_fast: "/org/gnome/terminal/legacy/" (establishing: 0, active: 0)

unwatch_fast: "/org/gnome/terminal/legacy/" (active: 0, establishing: 1)

watch_established: "/org/gnome/terminal/legacy/" (establishing: 0)

It Opens a terminal window:

CrossOver needs your permission to install missing packages.
This operation must be run as root:

sh -c "dnf install --best dbus-python gobject-introspection gtk3 nss-mdns.i686 nss-mdns.x86_64 python3-gobject"

Trying with sudo...
[sudo] password for jjmarin:
Last metadata expiration check: 0:47:42 ago on Sat 11 Jul 2020 08:19:05 PM CEST.
No match for argument: dbus-python
Package gobject-introspection-1.64.1-1.fc32.x86_64 is already installed.
Package gtk3-3.24.20-1.fc32.x86_64 is already installed.
Package gtk3-3.24.20-1.fc32.i686 is already installed.
Package nss-mdns-0.14.1-7.fc32.x86_64 is already installed.
Package python3-gobject-3.36.1-1.fc32.x86_64 is already installed.
Error: Unable to find a match: dbus-python
Finished. Press Return to continue.

Terminal Window closes after pressing Enter

More messages on the console:

Could not install some Unix packages
Some errors may prevent CrossOver Linux from working correctly:

• Could not load the D-Bus Python modules.
• Could not load the GObject-Introspection Python module.
• Could not load the GObject-Introspection data for GTK.
• Missing 32bit libnss_mdns.so.2 library

You may be able to fix some issues by running one of the following commands as root:
Arch Linux (32 bits) pacman -Syu gtk3 nss-mdns python-gobject python2-dbus
Arch Linux (64 bits) pacman -Syu gtk3 python-gobject python2-dbus
Debian 7 (32 bits) apt-get install gir1.2-gdkpixbuf-2.0 gir1.2-glib-2.0 gir1.2-gtk-3.0 gir1.2-pango-1.0 libnss-mdns python-dbus python3-gi python3-gi-cairo
Debian 7 (64 bits) apt-get install gir1.2-gdkpixbuf-2.0 gir1.2-glib-2.0 gir1.2-gtk-3.0 gir1.2-pango-1.0 lib32nss-mdns python-dbus python3-gi python3-gi-cairo
Debian 8 apt-get install libnss-mdns:i386
Debian <= 6 (32 bits) apt-get install gir1.2-gdkpixbuf-2.0 gir1.2-glib-2.0 gir1.2-gtk-3.0 gir1.2-pango-1.0 libnss-mdns python-dbus python3-gi python3-gi-cairo
Debian <= 6 (64 bits) apt-get install gir1.2-gdkpixbuf-2.0 gir1.2-glib-2.0 gir1.2-gtk-3.0 gir1.2-pango-1.0 lib32nss-mdns python-dbus python3-gi python3-gi-cairo
Fedora <= 13 (32 bits) yum install dbus-python gobject-introspection gtk3 nss-mdns python3-gobject
Fedora <= 13 (64 bits) yum install dbus-python gobject-introspection gtk3 nss-mdns.i686 nss-mdns.x86_64 python3-gobject
Mandriva /usr/sbin/urpmi dbus-python nss_mdns
openSUSE <= 11.2 (32 bits) zypper install dbus-1-python gtk3 nss-mdns python3-gobject
openSUSE <= 11.2 (64 bits) zypper install dbus-1-python gtk3 nss-mdns-32bit python3-gobject

Does anyone know a fix for this ?

It is strange, I have another Fedora 32 box, and CrossOver seems to work ok there. It has installed the dbus-python-devel package. Maybe this package is enough to make it work. I will try later and I will report here.

I've installed dbus-python-devel on the machine, but the problem persists.

pkcon search name dbus-python-devel
Searching by name [=]
Finished [=]
Installed dbus-python-devel-1.2.16-1.fc32.i686 (installed:fedora) Libraries and headers for dbus-python
Installed dbus-python-devel-1.2.16-1.fc32.x86_64 (installed:fedora) Libraries and headers for dbus-python

I've realised that this other machine was using Python from Anaconda. I switched to python provided by the systems and it works now.

Anyway, the fact that there isn't any dbus-python package in Fedora is something that it must be taken into account by the developers