A reoccurring problem I have been having lately is lack of support for applications that run AVX instructions, specifically. These softwares are unable to initialize on ARM architecture, a few culprits include;
1) Assassin's Creed: Odyssey (AVX, DX11, no Anti-Cheat) - Untested due to issues running Uplay.
2) Star Citizen (AVX, DX11.1, Easy Anti Cheat) - EAC blocks launch due to unsupported ARM architecture, bypassing the launcher and running the game client directly results in AVX error.
3) Age of Empires 4 (AVX, DX12, no Anti-cheat) - AVX workaround under linux using Intel SDE (target the games .exe) - someone else tested and working.
4) Cyberpunk 2077 (AVX, DX12, no Anti-cheat) - supposedly an .exe patch on Nexus Mods, untested.
This seems to be a common theme in more recent releases, and will need to be addressed as Crossover fails to run these titles without outside bypasses. There are currently projects to support AVX / SSE on ARM architecture (SIMDe - SIMD Everywhere, sse2neon etc), or perhaps Codeweavers is working on their own solution?
Either way, AVX support will only become more and more relevant as more games are released. With DX12 support already implemented in Linux, and coming to macOS (possibly in 2023) it would be a shame to have some of the most popular / desired games unsupported.