Since about CGX 8.1.4, I've had nearly flawless success with Sacrifice on the Mac, from OS X 10.5.8-10.6.4 on a GMA 950 MacBook (CD and C2D) and a MacBook Pro (128 MB Radeon Mobility X1600); this game still works great on CXG 9.1.
Performance may be choppy - but that's more of an issue with the way this title was coded; when it was first released it was widely criticized for performance issues even on higher-specced hardware, on both Windows and the Mac.
To avoid any potential graphic programs, be sure to leave the rendering preferences at their defaults; you may encounter issues with the mouse cursor not responding at the startup menu, so be sure to go into winecfg and turn off "Allow The Window Manager to Decorate the Window" and "Allow The Window Manager to Control the Window".