This is a temporary fix to bypass the problems on the current Steam and Mac client that does not allow Keyboard or Mouse input. This problem is caused by the overlay that steam has which is invisible once the game runs. In order to temporarily correct this issue take the following steps if you encounter them:
1. Manage Bottles, Select the bottle with Steam installed on it
2. Enter Control Panel
3. In the Control Panel click on "Add Application", and then find the Steam executable (in this case WormsReloaded.exe) this is usually found under the "common" folder in "steamapps", click Open.
4. Select Libraries tab in winecfg.
5. In the empty box next to "New override for library" type in GameOverlayRenderer or gameoverlayrenderer, it is not case sensitive. Click add.
6. Edit the newly created field for gameoverlayrenderer by clicking Edit.
7. Select Disable, click OK, and OK.
8. Your mouse and keyboard input should be enabled, however, the game is still known to crash occasionally from the mouse being stuck in certain bounding boxes.
via Ken, thanks.
