I found that information at the forum and thought it would be good to put in one place.
1. Install "Mac Driver" to get the Updater/Starter running properly.
http://www.codeweavers.com/compatibility/browse/name/?app_id=10937
2. Add some registry keys
Description: http://www.codeweavers.com/support/wiki/mac/mactutorial/registry_keys
Needed Registry Keys:
HKEY_CURRENT_USER\Software\Wine\AppDefaults\TheSecretWorld.exe
HKEY_CURRENT_USER\Software\Wine\AppDefaults\TheSecretWorld.exe\Direct3D
Needed Values:
StrictDrawOrdering = enabled -> Show Intro Movies and stop Display flickering
It´s running playable with some glitches on my 2012 iMac 21.5 but the performance is not very well.
Still trying and extending this list.