Update - When at the change video system screen, check the "show all" check box - Then choose "OpenGL" as the driver of choice. Rune runs great now on my system!!
Rune will install and run from the Windows installer CDROM. But, the uv mapping is somehow not rendering properly. As such, you can see through some walls and objects, and this 'visibility' flickers, making the game almost impossible to play.
Installed in a Win98 Bottle, will try Win2K later.
System: Apple iMac (late 2006) Intel Core 2 Duo T7400@2.16GHz, 2GB RAM (Apple), ATI Mobility Radeon X1600 w/256MB VRAM, System software Macintosh OS X 10.4.8.