After installing Osmos in a new bottle, install Microsoft Visual C++ 2005 Redistributable in that bottle. Unless OpenAL is supported, you have to get NR_OpenAL_AddOn.7z (first post on the page), extract it with 7zip and drop the files into your Osmos directory (something like .cxgames/Osmos/drive_c/Program\ Files/Osmos/). Please be aware that these files might contain malware.
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