Haven't tested under Mac yet, but this is how I got it working on Debian Lenny...
(help taken from http://www.scripture4all.org/ISA2_help/FAQ/ISA_faq.htm#ISAandLinux)
After installing ISA2, copy USP10.DLL from windows\system32 on a windows system (perhaps this is available on the net as well), and place it in your ~/.cxoffice/<bottle_name>/drive_c/windows/system32 folder.
Go to Applications -> Crossover -> Configuration
Switch to Manage Bottles tab
Select your bottle and click configure
Switch to the Control Panel tab
Click winecfg
Add ISA.exe to the application list (default location drive_c/program files/ISA2)
Select ISA.exe and click the Libraries tab
Type in USP10.dll and click Add
Click Ok on all the windows you opened
** For the fonts, I had to install the ttf-mscorefonts-installer package on Lenny. I'm not sure what this package would be called in any other distro, but it should be similar. I'd love to have other Linux users try this out on something other than Debian/Ubuntu and see if you can add to this. These are the standard windows fonts.
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