Make the following changes to the registry to enable sub-pixel font rendering:
Browse to [HKEY_CURRENT_USER\Control Panel\Desktop] and create/update the following “DWord” values (note: the DWord values are hexadecimal, which is the default for entering values in regedit.exe). You may have to create several of these, since by default only the “FontSmoothing” registry setting is present:
"FontSmoothing"="2"
"FontSmoothingType"=dword:00000002
"FontSmoothingGamma"=dword:00000578
"FontSmoothingOrientation"=dword:0000000
Then, restart your Wine applications and watch the difference in font rendering. The jagged edges should have disappeared. As an example, here are two screenshots from sections of winefile, before and after the registry hack. Click on the images to see the full version. Thedefault font used in winefile is quite small (6 point) but here it makes the changes in fort rendering even more obvious.