ePSXe is based upon a plugin architecture and compatibility with CrossOver varies as a result (depending on the combination of plugins used). The base ePSXe program works without a hitch, but once you start playing games is where campatiblity is iffy. From my initial testing, most of the sound plugins work as well as the input (cd-rom or iso) work just fine, its the video plugin that seems to make or break it. So far the plugin that works the best (in full screen and windowed) is the "Pete's OpenGL Driver 1.76" set to the 'Fast' preset. When using that plugin ePSXe runs flawlessly, but your mileage may vary depending on if you up the quality of the settings (but I'm still testing). Have fun ;)
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