If your client seems to run ... patches, and game begins to load, but "hangs" (crashes actually), just as the character screen is about to load try the following... (This works with 10.0.1)
Launch CXG
Use the pulldown, Configure/Manage Bottles; select your DDO bottle; select Wine Configuration.
Click the LIbraries tab.
To the right of the "New Override for the LIbrary" click on the triangle.
Scroll down the list to "openal32.dll"; Select it, click add.
This should bring up a highlighted entry in the "Existing Overrides" window below.
Click edit; select "Native (Windows)" click ok.
Close Wine Configuration; close manage bottles
Launch PyLotRO.
Log in and you should be good to go.