If the game crashes on startup with the following error: "The program DKII.exe has encountered a serious problem and needs to close. We are sorry for the inconvenience." Then it is very probable that it's because of the safedisc copy protection.
To avoid safedisc issues (Wine bug 219), your only option is to find a crack. This is illegal in some countries, so you should investigate the legal issues before you to do this.
If you have now obtained a crack Dkii.exe in a zip file DK2UK17.ZIP, simply extract it into the program directory (ensure this is the correct path for you):
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