For the Origin version of the game, make sure to install "Direct X for Modern Games" into the same bottle (should be a Win7 x64 bottle), and in the game properties within Dead Space through Origin, make sure to disable the "Enable Origin in Game for Dead Space (2008)" option.
There is quite a bit of stuttering and audio issues that I still haven't solved, but this got the game running in a playable-enough state.
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