If you are running Cargo! The Quest for Gravity on a Mac, you will find that the mouse quickly becomes unusable.
To fix this, select Programs -> Run Command... in CrossOver and use the dialogue box that appears to run "regedit" in bottle that contains Cargo! The Quest for Gravity. Now drill down into HKEY_CURRENT_USER -> Software -> Wine -> DirectInput. The DirectInput folder might not exist and if so, create it by selecting Edit -> New -> Key in regedit. Now select Edit -> New -> String Value and create a new string value with the name MouseWarpOverride. Give it the value "force_edge".
Alternatively, you can create a plain text file called cargo.reg with following text in it (just cut and paste it)
REGEDIT4
[HKEY_CURRENT_USER\Software\Wine\DirectInput]
"MouseWarpOverride"="force_edge"
and then use the Registry -> Import Registry File... menu item to import the file.