Using CrossOver Games 8.1.4 on a MacBook (2.4 GHz Core 2 Duo, 2 GB RAM, NVidia GeForce 9400M) running OS X 10.6.2, I found Wizardry 8 to be one of the easier and more fully functioning applications I've installed.
After creating a new Windows 2000 bottle, I installed the game and then the official 1.2.4 patch (also named the 2001_12_23_release patch). I then applied the Wizardry 8 v1.2.4 No-CD patch, and the Unofficial Wizardry 8 OpenGL Patch.
I configured CrossOver to run in a virtual desktop with 800x600 resolution. I set the game's internal configuration to match that resolution and to display graphics using OpenGL.
The game ran perfectly fine, with no problems other than the opening Bink-format (.bik) movies not displaying. However, I found that by setting the game to run fullscreen the Bink-format movies did play just fine. Because I prefer to play in windowed mode, I installed the Bink Rad Tools (from www.radgametools.com) into the same bottle so that I could just manually run the movies while continuing to play in windowed mode. I felt this was a reasonable compromise since there are only a couple of movies that will need to be displayed throughout the entire game.