I have a 1440 by 900 monitor. Uplink otherwise works perfectly for me, but setting the resolution to 1440 by 900 or 875 screws up the game's display. Buttons are partially cut off on the bottoms, and the game thinks the cursor is much higher than it actually is. Another problem is that you can't change it back easily, because in order to apply changes to resolution settings, you have to click the apply button, which is at the very bottom of the screen, and it's unclickable because the game things the cursor is above it when it's actually at the bottom of the screen. I fixed this problem by uninstalling Uplink, clearing the settings and save games manually in the C drive, reinstalling it, and choosing a smaller screen resolution.