There's a total graphical conversion mod for Uplink called "Uplink OS", including both new graphical assets and a new binary. It does fix the fullscreen problems others have reported where only the upper-left 2/3rds of the screen is visible, and it also fixes the small font-size problems associated with running in windowed mode as one of the tips suggests.
Unfortunately it hangs on character registration, though, so you can't actually play the game. This occurs at least on Crossover 24.05 on an Intel Mac running Ventura in a Windows 10 64-bit bottle created via the Steam Crosstie with DXVK enabled. I haven't tried messing with settings much to see if there's a recipe that makes "Uplink OS" work. If there is such a recipe, it seems like the nicest way to play uplink these days... especially given the hassles of other approaches on Crossover.
If you want to try it out, Uplink OS is available at https://www.moddb.com/mods/uplink-os.