Installed from original release CD fine. Tried to run and it failed. Installed the 436 patch from www.epicgames.com. Started again and ran fine. Changed resolution to 1200x800 and fiddled with all settings with only sound issues and connected to a server (and downloaded a custom map) and played for 10 minutes with no issues.
The sound issue is that while the game responds fine the sound sometimes lags behind by about half a second. While not a a major problem it can be off putting. Possibly down to specification of my Mac though.
Tried this as I had the Windows version lying around.
Running Mac OSX 10.4.8 and Crossover 6.0 Beta 3