Although its precursor "Twelve Sky" works with minimal effort, the new Twelve Sky 2 does not. ...and possibly never will.
The game uses GameGuard as part of an anti-hacking/cheating system. GameGuard uses libraries from Oreans to achieve this. ...and Oreans seemily has no interest in working with the WINE community (including CodeWeavers) to address the compatibility issue.
Twelve Sky 2 can easily be seen as an expansion pack and engine update to the original Twelve Sky - at its core, it is the exact same game. For those itchin' to get their PvP on in ancient China, give the first one a chance.