I've played through the first 8 chapters and haven't had any problems:
I'm running mac OSX 10.5.2, on a mac book, with the GMA950 graphics chip.
I set up a 98 bottle (couldn't get it to run on a xp bottle even though it says it works in xp on the disk). I then installed Dcom98, the html engine, and IE6. (i also have WMP9 on there but i'm pretty sure that makes no difference). This then allowed me to install the game.
Once installed you need to run the winecfg tool from the control panel in 'manage bottles' and select the virtual desktop option, and then enter a resolution (both 800600 and 1024768 work for me). apply this and you can play away!
My version of the game is already patched (bought it from the sold out range) so you may need to patch it before running it.
I do occasional get a cursor displacement problem, where the cursor image is not at the point the cursor is on. I find clicking in and out of a crossover/wine/bottle window solves this.
Hope this helps
[just to add, i couldn't get it to run on crossover games, but i got it running on crossover as described above]