I created an image of the DVD with a Windows machine, unpacked that image on my Mac and ran the setup.exe via CrossOver. After installation I applied the NoCD and Widescreen-Fix, however I haven't gotten the latter to work yet.
When running at the games native full resolution of (1280x1024) it's starting in window-mode only as this exceeds my laptops resolution in width (only 1440x900). In window mode I do get glitches in the 3D-engine, which causes blue smearing and gameplay doesn't work at all. However when using a smaller resolution (1024x768), the game runs in fullscreen-mode without a problem.
I do get a bit of stutter upon each start of a new run/level, but that's not impacting the gameplay.