Since I upgraded to 16.1.0, I have twice had my mouse buttons (left and right) stop working completely. In Witcher that is actually a real pain, as the menus to save, exit etc require mouse clicks rather than keyboard returns.
Last time this happened I pressed F5 to save and then it started working again. I would be interested in whether anyone else has seen this in Witcher on Crossover. I have not yet seen it anywhere else (and it never happened on earlier Crossover versions), but I have not completely ruled out an issue with my mouse.