The GOG installer always hangs with an unknown error towards the end requiring me to force it to close; this appears to be during installation of redistributables as the installation succeeds otherwise (Note: I already installed all required redistributables prior to running the installer for TW2, but the crash happens regardless of whether I do this or not). This also happens with the GOG installer for The Witcher.
The game's launcher sometimes works (sometimes taking a while to become visible), sometimes not.
Ingame there is some significant graphical glitching during certain cutscenes which appears to be a lighting/shading issue. During gameplay there is an issue with Geralt's face when standing in front of certain vegetation (the vegetation appears completely black until you get close to it).
Aside from these issues, the game is playable.
System specs:
Linux Mint 15 KDE 64-bit
i7 2600k @ 4.5GHz
8GB RAM
Nvidia GTX 570 / driver version 313.30