For reference: Skyrim seems to work mostly well on a late-2013 15" retina MacBook Pro with the discrete GPU (NVIDIA GeForce GT 750M), running OS X Mavericks. At 2880x1800 resolution the framerate was too low (unsurprisingly), but I'm now running at 1440x900 at the Medium group of video settings, and only rarely does the framerate drop so I notice. (I'm not a hardcore gamer, so my standards may be low.)
The only bug I've noticed is that when exiting the game, it instantly hangs (not appearing to accept any input, and not updating the screen). From there, I am able to Cmd-Tab back to Steam (running in the same bottle, I think?), and can force-quit Skyrim with no apparent side-effects.