We believe that the 360-degree mouselook issue in Skyrim has been resolved in our latest beta, CrossOver 12.
In order to have the good mouselook, it is necessary to run Skyrim with the experimental driver listed in the 'Advanced' tab of the 'Manage Bottles' window.
If you play Skyrim, we would love your feedback on how it is working with the experimental driver!
If you want to play Skyrim on the CrossOver 12 Beta, you can download the beta from here:
http://www.codeweavers.com/xfer/duboisj/cxbeta/
... and use this key
trybeta
to access the beta. Again, for existing Skyrim installs, you will have to go to the 'Advanced' tab of our 'Manage Bottles' dialog and enable the experimental IMG driver.
CrossOver 12 will be have an official release in a few weeks. For now, for our Skyrim fans, try with the beta and let us know how it works!
Cheers!