The main reason I was interested in Wine or Crossover, is Sketchup. I have designed my house with it, and after switching to Ubuntu, I still want to be able to draw with Sketchup.
My first attempt, with Crossover, did not get me past the splash screen. Then I got some OpenGL exception.
Installing it with Wine, and changing a registry key to enable HW_OK did the trick.
The default short cut keys were not enabled, but choosing "Reset all" fixed that.