Ok folks, here is what I can get it to do:
The installer fails, citing an error with Program Manager. This is after it copies all of the files over, though, so I can get around that, I just have to run the program by hand.
The text in the boxes at the top of the main view that would have all the dynamically updated things, like money and population and what not, are all not visible.
Whenever the player clicks on something like the Airport or the Seaport button, the rest of the buttons go away and the user has to move the mouse over them to get them to work again.
Finally, the build box is a little funny. It's striped instead of just a solid lighter color. Other than that, the app works perfectly.
All of these issues were with CxOffice 2.1 Trial. I will be trying out a nightly build soon.