As of writing, the update to RIFT patch 1.3 Hotfix #4 has broken compatibility. What we're seeing is that after logging in, pressing "play" on the launcher client is useless, and the game never fully launches.
This behavior is present with Crossover Games 10.1 and the "hacked" version we put out yesterday to fix Hotfix #3.
We're working on it, and will post updates to this thread as we get them.