I followed all the steps I've read about getting this game running. It says it installs fine, but when I go to run it, it shows some screwed up stuff (like chopped up versions of my current screen) on the screen, and then goes black. After this, nothing.
I found http://www.gamersonlinux.com/forum/threads/quest-for-glory-5-guide.575/ which explicitly uses a certain version of Wine, and I guess I can't choose a version with Crossover.
I'd say that this doesn't work at all.