Tested the GOG.com version included with the Quest for Glory 1-5 pack (1-4 use DOSBox, and therefore don't need CrossOver). The game runs perfectly but runs into the annoying bug that prevents play in fullscreen under Lion – requiring use of a Virtual Desktop. I haven't had the chance to play this on Snow Leopard, but on 10.6 this game likely does work on true fullscreen.
MacBook Air (2010), 10.7.5, CXG 11.2.2.