After last nights update to Once Human - it appears to be working via Crossover Preview again (I haven't tested it against the non preview version). I did have to switch the game config back from DirectX 12 to DirectX 11.
I'm currently using D3DMetal / MSync, however it appears to also be working with DXVK.
In game (currently running on High) - I did modify the Super Resolution setting from "NONE" to Quality. This resolved some very fuzzy ground cover (bushes, leaves, etc).
This is on a MacBook M4 Max