Someone (Codeweavers?) added a block of text to many of the tips for NWN2:
"The Digital Rights Management (DRM) software in this program
prevents it from running in CrossOver. If you are in a legal jurisdiction
which allows removal of such software, you may have luck running this
program. Unfortunately, CodeWeavers, because they are subject to the
Digital Millennium Copyright Act, will be unable to support you. "
This is incorrect. The 1.23 patch (which came out a couple months ago), released by Atari/Obsidian, removed the SecureROM DRM that prevented the game from running without the disc.