I can get Myst IV to install and correctly populate CrossOver's "Program" menu. Myst's installed utilities all work correctly (they identify the WinXP environment and suggest the game is able to work - it does suggest the graphics driver may not be up to date.)
When the application is launched, the system crashes in the process of checking the DVD before launching the game. There is something not acknowledging the DVD being inserted into the drive, and the game halts unable to verify the disk is valid.
I think this is something in the copy protection or X11's interface to the DVD drive that is causing the application to mis-read the disk.