System Specs:
2.4 GHz Intel Core 2 Duo
Mac OS X 10.6.6
2GB RAM
nVidia 8600
Crossover 10
Works great! Wish I could say the same for the earlier Myst games (Riven and Myst are not working at this point, for me anyway)
Anyway, to get this running, insert the install DVD (Should be Disc 1) and install the game in a new XP Bottle. You can either install Quicktime and DirectX from the disc, or the versions provided from the Community Supported Applications and Runtime Support Components drop down menus, respectively.
When you insert the second DVD to run the game, it will start, but you will get an error stating the DVD is not inserted. Apply the obvious workaround to this problem and the game starts normally, and works like a charm!