I had a hard time trying to get office 365 and office 2013 to work on my KDE Neon (deb-based distro with KDE).
The same issues may arise on several different deb-based distros, including Ubuntu.
The problem was hardly definable: office would install, but would hang forever at splash, or crash, when started. This was not the usual issue with registration or so. This was a completely different issue. A bad one.
Turned out, after a conversation with the Support, guys, that it was an issue with OpenGL. Pretty clear from the beginning, indeed, if I only bothered to read the warning during the office 365 installation early stages: crossover clearly stated that OpenGL was not working and that this would lead to issues with some games... well we can discuss whether office 365 is just a toy or not, but, wow, I could never imagine that it would need OpenGL to run!
Anyway, the problem was that the nvidia repositories install a version of the libraries that is not compatible with the opengl 32 bit libraries needed to run office365 under crossover. As a consequence, I had to remove all nvidia stuff from my pc and re-install everything from the scratch, following a specific order and from specific sources. The inspiration comes from this LINK
I also had CUDA and CUDNN installed, so had to remove and re-install them. If you do not need them or do not know what they are, just disregard their (re-)installation.
I hope this can help.