Well, Frontpage 2002 works somehow with CrossOver. You have to make sure first, that all your files of a project are read- and writeable. Uploads work but the internal update after an upload not. That is to say that Frontpage hangs after the upload has been done. Having open more than one pages might lead to minor problems, too, as it is not possible to switch between pages.
Summary: using Frontpage 2002 for large sites is currently not recommende. I will do some more test with upcomming version 4.1, but are more interested in Frontpage 2003 (see there for more infos).