I'm using Excel XP with Crossover 6.2. It runs fine at first, but if I switch to a new window and the switch back, the mouse alignment between OS X and the Excel window doesn't match up. Excel seems to think my mouse is 5 rows down and 2 rows to the right of wherever I'm actually clicking. I can still navigate with the keyboard fine, but it's impossible to use the buttons/menus at the top of the window.