I was getting a C++ runtime error R6034. Microsoft's documentation indicated it was due to loading runtime files without a manifest, blah, blah, blah. The real problem was that two conflicting dll's were being loaded. They are: msvcr80.dll and msvcr80d.dll with msvcr80(no d) being the offender. I was able to get around this by changing the dll load order in Manage Bottles>Control Panel>Wine Configuration from native/builtin to builtin/native. This alone changed the load behavior from the error code mentioned to hanging up for Access, and at the same time Excel threw a No OPL error message. I then disabled the NPOFF12.DLL plugin under Manage Bottles>Control Panel>Plugins and voila both Excel and Access ran without errors. I have not used them extensively, but to this point, there does not appear to be a "domino effect", but there may well be under different usage. Thought I would post and let others try with different usages, etc.
I am running Ubuntu 11.04 with only Access, Excel and the other default support installs in a bottle.