I have been using CrossOver for years, in order to run MetaTrade 4 with great success and without bugs, including CrossOver 21.2.0.
Unfortunately, the new version CrossOver 22 is unable to provide the same performance and results with MetaTrader 4.
My MT4 instance got frozen twice in less than one hour, right after a fresh installation of MT4, this happened while I was adding indicators.
Also, when I was browsing from the MT4 instance, to different folders inside my PC, in order to copy and paste indicators to MT4, I noticed that the very basic function copy/paste did not work.
I hope this bugs get fixed soon. since these issues are just new and brought by CrossOver 22, but not previous CrossOver versions.