My comments have to do with my own experience with LTSpice and CrossOver on a mac.
Some changes have happened in CrossOver (and/or Wine?) since since the last post was made that interfere with some key combinations from being handled correctly and due to the inability in LTSpice to change every key mapping and the lack of flexibility for key mapping in Crossover and Wine in general some LTspice functionality is broken. That said, if you don't need those particular features or can work around them then LTspiceIV may work just fine for your needs. For students who only need to use LTspice for a couple of classes you may get annoyed but you will still be able to get done what you need to with the menu instead of using the keyboard shortcuts. If you are only getting Crossover to run this one program, save yourself some money and download Wine. It works as well or better for LTSpice. Crossover doesn't bring anything to the table that will help you with LTspice that isn't in the free versions of WIne.
Because not a lot of people are voting for LTspiceIV to be fully supported, Codeweavers has really done nothing with my support requests about the problem. In fact I never even received a reply to the last communication several months ago. So, if you really need LTspice to work at its best, Crossover is not currently the solution. It does work perfectly under Parallels running Windows XP though Parallels is not a great program and of course neither is Windows. I have had to resort to this because I want the keyboard shortcuts to all work, not just most of them. For what it is worth, several professors at OIT use VMware and Windows for LTSpice on a mac and other than normal Windows issues and complications that arise from using virtualization software in general this combination is probably equal to that of using Parallels though I have not personally tried it.
~Chris