I've successfully installed Notes 6.5.3. I installed from scratch from the self-extracting exe version, and I used the supported "Notes 6.5.1" option in cxsetup to do it. It installed DCOM95, IE6, etc, for me as well.
Notes launches fine, but when I do the very initial setup dialog, where you specify the name of your Domino server, it doesn't work. I have both the Lotus name of the server and the real hostname and IP address of the server, but the notes client keeps telling me that the server isn't responding (reboot to windows on same machine and use same values, works fine). This is in a corp environment, one difference I can think of is that my linux/crossover box isn't in the corp NT domain, whereas when I reboot to windows I am (is there a way to "join" the domain from my fake_windows onder cxoffice?). The IE6 that cxsetup installed for me reaches out and touches all the websites around here fine, so I know basic IP networking is working ok.
Any thoughts?