I attempted to run the Windows version of KSP on my Mac. Since KSP doesn't have an installer, I just decided to run KSP.exe as the installer. CrossOver started the game which loaded up just fine. However, when I encountered a dialog box that some nonstandard UI elements, I found that I could click on the elements but the click didn't actually register with KSP.
I wasn't able to get very far but there is a version specifically for Mac so I'm not too worried. Sorry Linux guys.