After installing the "Microsoft Visual C++ 2005 Redistributable" iTunes 10.1 installs and runs. iTunes takes a long time to start, upwards of 20 seconds or more (2.8Ghz Core2 Duo). Application always complains about not being properly installed, and unable to burn CD's. Navigating the iTunes Store seems to work as expected, previews play but no sound. Selecting video previews crashes iTunes. I am able to import MP3's into my iTunes library, and play them, sometimes I get sound, sometimes I dont. Selecting video's (even tutorials) will crash iTunes. As expected, iPhone and iPod sync does not work, not sure it ever will. In a nutshell, it starts, but is generally worthless.