IDA Pro 5.0 works fairly well under the Crossover Mac beta. A couple of tips:
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You will probably need to change the font under Options -> Font -- when I started it up, everything was in an italic font. This was easily fixed.
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The graph mode occasionally crashes with very large files (exe > 20 MB).
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Sometimes, the autoanalysis will stop; the program is still responsive, and any interaction with the program will cause it to resume.
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As mentioned above in the comment about IDA 4.3, the menu bar doesn't work. To fix this problem, go to the Crossover Configure menu -> Control Panel -> Winecfg -> Graphics, and de-select "Allow the window manager to control the windows".