I got the demo installed on my Mac Pro in a WinXP bottle in Crossover Mac Games. The game installs and runs to the title screen, and the title screen options can be selected with the arrow keys and return, but the mouse isn't recognised at all.
Without the mouse working I cannot get in to the game proper to test further.
Edit: I can enter the game, I'm just not able to do much not having mouselook. However, the game runs, it's smooth, and I can kill a few zombies before the game unfairly wants me to turn to a different direction. It looks like if the mouse is made to work the game will be fully playable.