In the Crossover window with the Guild Wars 2 bottle selected, I see two Guild Wars 2 game icons. They seem to be the same thing, though I use the first to launch it. I've just experimented briefly and switching from DXVK to D3DMetal worked and dramatically speeded up the frame rate and let it Auto Select better settings. (Still fairly low-medium settings, but that it looks at least as good as what I'd been running when it was still supported on the Mac.)
[Just saw another post to also enable MSync, which I've now done.]
I'll report back with more details when I've tried it in high-population zones, but so far so good.
This is using MacOS Sequoia 15.1.1 and an M4 Max.