Grim Fandango currently installs just fine via the crosstie. But the game is in definite need of the official 1.01 update, and installing that is slightly more complicated:
1. Download the update, preferably from the [official site](http://www.lucasarts.com/support/update/grim.html), or try the [direct FTP link](ftp://ftp.lucasarts.com/patches/pc/Gfupd101.exe).
2. Copy the .exe file into the /Program Files/Lucasarts/Grim/ folder.
3. Launch the "Run a Windows Command" program from CrossOver Games, select the Grim bottle, select the update .exe as the program to run, and click OK.
4. Follow the instructions and you're done!
As an alternative to steps 2 and 3, you can run this command:
~/cxgames/bin/wine --bottle "Your Grim Bottle" start /unix "/path/to/Gfupd101.exe"