On my i7 iMac with 10.6.5, 8GB RAM and Radeon 5750 GPU this games installs and runs fine, but the gameplay is a bit off.
Specifically, the mouse movement is very slow and not very precise, it's bad enough that on the early levels by the time that you are able to lock onto the enemies they are already having their way with you. I tried upping the mouse sensitivity in the options, as well as on my mouse, and it actually harms more than help, making it too twitchy.
This is actually an improvement over Crossover Games 9.1 where the textures didn't load correctly. There is also an issue with the options menu being partially hidden behind the dock, making it hard to navigate to swap from the Crossover default resolution.
EDIT
They have added a launcher to the game, so you can select the proper resolution from the start, the mouse issue still persists, making the game unplayable, though.