The game seems to work alright, actually, except for a few minor irritances.
First, there is a problem with the turning radius being limited because of the mouse hitting the edges of the screen. Changing the wine configuration to stop the mouse from leaving the window does not seem to help. I am sure this can be easily fixed, though.
The only other problem I noticed was that the top 8 or so menu items do not show on the 'esc' menu. This is not really a problem if you know the hotkeys for these menu items, and if you know where the item is normally, you can still click it without seeing it. This might actually be a problem with anti-aliasing, as I have heard users on windows having this problem because of forcing anti-aliasing.
Other than that, the game seems to run fine, despite it's .net 3.5 requirements. Any ideas?